目的 研究宾川獐牙菜的化学成分。方法 常规硅胶柱色谱和薄层色谱进行分离纯化,根据化合物的理化性质,现代波谱方法鉴定其结构。结果 从宾川獐牙菜中分离得到5个化合物,分别为7-O-【α-L-吡喃鼠李糖-(1→2)-β-D-吡喃木糖】-1,8-二羟基-3-甲氧基酮(1),3-O-β-D-吡喃葡萄糖-1,8-二羟基-5-甲氧基酮(2),7-O-β-D-吡喃葡萄糖-1, 8-二羟基-3-甲氧基酮(3),当药苦酯苷(4),羟基当药苦酯苷(5)。结论 5个化合物均为首次从宾川獐牙菜中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of Swertia binchuanensis. METHODS The constituents were isolated and purified by column chromatography of silica gel. Their structures were identified on the basis of spectral analysis and chemical properties. RESULTS Five compounds are isolated and identified as 7-O-【α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl】-1,8-dihydroxy-3-methoxyxanthone(1), 3-O-β-D-glucopyranosyl-1,8-dihydroxyl-5-methoxyxanthone(2), 7-O-β-D- glucopyranosyl-1,8-dihydroxyl-3-methoxyxanthone(3), amarogentin(4), and amaroswerin(5). CONCLUSION All of the compounds were isolated from S.binchuanensis for the first time.
关键词
宾川獐牙菜 /
酮 /
环烯醚萜苷 /
7-O-【α-L-吡喃鼠李糖-(1→2)-β-D-吡喃木糖】-1 /
8-二羟基-3-甲氧基酮 /
3-O-β-D-吡喃葡萄糖-1 /
8-二羟基-5-甲氧基酮 /
7-O-β-D-吡喃葡萄糖-1 /
8-二羟基-3-甲氧基酮
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Key words
Swertia binchuanensis /
xanthone /
iridoid glycoside /
7-O-【α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl】-1,8-dihydroxy-3-methoxyxanthone /
3-O-β-D-glucopyranosyl-1,8-dihydroxyl-5-methoxyxanthone /
7-O-β-D-glucopyranosyl-1,8-dihydroxyl-3-methoxyxanthone
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中图分类号：
R284
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参考文献
[1] COUNCIL OF THE FLORA OF CHINA EDITORS. Flora of China Vol. 62(中国植物志第62卷). [M]. Beijing: Science Press Ltd, 1988:344.
[2] SUN H F, HU B L, DING J Y, et al. The glucosides from Swertia mussotii franch[J]. Acta Bot Sin(植物学报), 1991, 33(1):31-37.
[3] PAN L, ZHANG X F, WANG M K, et al. Studies on chemical constituents of Swertia przewalskii [J]. Chin Tradit Herb Drugs(中草药), 2002, 33(7):584-586.
[4] CAI L, WANG S, LI T, et al. The phytochemical research of Swertia chirayita [J]. West China J Pharm Sci(华西药学杂志), 2006, 21(2):111-113.
[5] MA Y. Studies on constituents and ant-liver injury effect of tibetan medicine Zang Yin-chen [D]. Beijing:Minzu University of Chin, 2011, 3:36-37.
[6] ZHANG X Q, HUANG F J, CHENG J C, et al. Study on xanthones with anti HBV virus activity from Swertia extract [J]. J Chin Med Mater(中药材), 2006, 29(7):697-699.
[7] HU D H, GAO Y, SHAO C, et al.Studies on hypericin in Hypericum perforatum L and it′s interactions with HIV-1 Rt [J]. J Mole Sci(分子科学学报), 2008, 24(4):280-283.
[8] GULICK ROY M. Phase I studies of hypericin, the active compound in St. John, s wort, as an antiretroviral agent in HIV-infected adults:AIDS clinical trialsgroup protocols 150 and 258[J]. Ann Intern Med, 1999, 130(6):510-514.
[9] LI S X, WANG T, TIAN Q, et al.Chemical constituents from Swertia cincta Burk. and their antagonistic effects on benign prostatic hyperplasia[J]. Chin Pharm J(中国药学杂志), 2015, 50(6):502-506.
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脚注
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基金
云南省自然科学基金资助项目(2009ZC122M);云南省教育厅科学研究基金资助项目(2012Y153);大理学院2011年青年基金项目
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